DESCRIPTIVE ANALYSIS OF PRIMARY BREAST TUMORS CHARACTERISTICS IN PATIENTS WITH BONE METASTASIS

  • A. C. Tutovanu
  • Georgiana Radu The University of Medicine and Pharmacy "Carol Davila", Bucharest, Romania;
  • S. M. Oprescu
Keywords: breast cancer, bone metastases, ER, PR, HER2, bone

Abstract

Breast cancer is a severe disease with high morbidity and mortality affecting both women and men from all around the world. When it does not get diagnosed in early stages it metastasizes to other organs and tissues, thus becoming incurable. In addition, between 25-50% of patients will suffer from a metastatic development after the initial treatment. The most common locations are the bones, the liver, the lungs and the nervous system. The current research is an analysis of the molecular, macroscopic and microscopic characteristics of tumors in a cohort of 67 female patients with bone metastases from an initial breast neoplasm.

References

1. Union E. ESMO Minimum Clinical Recommendations for diagnosis , treatment and follow-up of locally recurrent or metastatic breast cancer ( MBC ). 2005;16(Supplement 1):10-12. doi:10.1093/annonc/mdi816
2. Asia S, Asia S, Hdi H. Source: Globocan 2018. 2019;876:2018-2019.
3. Corbu M. Situația cancerului mamar avansat în România: lansarea campaniei „Câștigăm speranță pentru femeile din România”. raportuldegarda.ro. https://raportuldegarda.ro/articol/situatia-cancer-mamar-avansat-romania-lansare-campania-castigam-speranta-femeile-romania-fundatia-renasterea-inomed/. Published 2018.
4. Autier P et al. Mammography screening: A major issue in medicine. Eur J Cancer. 90:34-62.
5. Kataja V, Castiglione M. Locally recurrent or metastatic breast cancer : ESMO Clinical Recommendations for diagnosis , treatment and. 2008;19(Supplement 2):19-21. doi:10.1093/annonc/mdn072
6. Octombrie L, Mondial L, Parteneri CC, Campaniei O. Comunicat de pres ă. 2011.
7. Howell A, Anderson AS, Clarke RB, et al. Risk determination and prevention of breast cancer. 2014:1-19.
8. DeVita VT, Rosenberg SA, Lawrence TS. Cancer: Principles and Practice of Oncology. 11th ed. Lipincott; 2018.
9. Metastatic Cancer. National Cancer Institute. https://www.cancer.gov/types/metastatic-cancer#where-cancer-spreads. Published 2017. Accessed November 20, 2019.
10. Kolb AD, Shupp AB, Mukhopadhyay D, Marini FC, Bussard KM. Osteoblasts are “ educated ” by crosstalk with metastatic breast cancer cells in the bone tumor microenvironment. 2019:1-30.
Published
2019-12-30
How to Cite
Tutovanu, A., Radu, G., & Oprescu, S. (2019). DESCRIPTIVE ANALYSIS OF PRIMARY BREAST TUMORS CHARACTERISTICS IN PATIENTS WITH BONE METASTASIS. Romanian Journal of Clinical Research, 2(2). https://doi.org/10.33695/rjcr.v2i2.34
Section
Articles