SISTER MARY JOSEPH’S NODULE: FIRST SIGN OF CHOLANGIOCARCINOMA RECURRENCE
Keywords:
Sister Mary Joseph’s nodule, cholangiocarcinoma, periumbilical metastases
Abstract
A sign manifesting an advanced abdominal cancer is the periumbilical metastases, also known as the Sister Mary Joseph’s nodule (SJN). As much as gastric, colorectal and ovarian malignancy are the most common cause, pancreatico-biliary advanced cancers were also reported to be responsible for SJN. We report the case of a 61-year-old male diagnosed and operated for a Bismuth Corlette type II hilar cholangiocarcinoma . 11 months after the operation the patient presented with a painless periumbilical tumor. A peritoneal biopsy and excision of the umbilical nodule was performed. The pathology result confirmed peritoneal and umbilical metastases from cholangiocarcinoma. PubMed research was performed revealing eight reported cases of SJN as a sign of cholangiocarcinoma. To our knowledge this is the first case of recurrent cholangiocarcinoma presenting as a SMJN to be diagnosed clinically at a routine checkup.
References
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[2] M. Premkumar et al., “Cholangicarcinoma Presenting as a Sister Mary Joseph Nodule,” ACG Case Reports Journal, vol. 3, no. 1, pp. 209–211, 2016, doi: 10.14309/crj.2016.52.
[3] I. Schoijet, A. Rojas, C. Cortés, and C. Varela, “Sister mary joseph’s nodule: from the history to the images. a case-based literature review,” Acta Gastroenterol Latinoam, vol. 48, no. 2, pp. 82–89, 2018,
[4] V. G. Galvan, “Sister Mary Joseph’s Nodule,” Annals of Internal Medicine, vol. 128, no. 5, p. 410, Mar. 1998, doi: 10.7326/0003-4819-128-5-199803010-00017.
[5] S. Tso, J. Brockley, H. Recica, and A. Ilchyshyn, “Sister Mary Joseph’s nodule: an unusual but important physical finding characteristic of widespread internal malignancy,” British Journal of General Practice, vol. 63, no. 615, pp. 551–552, Oct. 2013, doi: 10.3399/bjgp13x673900.
[6] I. H. Dar, M. A. Kamili, S. H. Dar, and F. A. Kuchaai, “Sister Mary Joseph nodule-A case report with review of literature,” Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences, vol. 14, no. 6, pp. 385–7, 2009. Available: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3129082/
[7] P. Garg, D. Mohanty, V. Jaswal, and V. Agrawal, “Umbilical nodule in cholangiocarcinoma,” Saudi Journal of Gastroenterology, vol. 18, no. 5, p. 345, 2012, doi: 10.4103/1319-3767.101143.
[8] M. C. Reichert, G. Farmakis, R. M. Bohle, F. Lammert, and V. Zimmer, “Cholangiocarcinoma Presenting as Sister Mary Joseph’s Nodule: Case Report and Short Review of the Literature,” Journal of Gastrointestinal Cancer, vol. 45, no. 2, pp. 231–233, May 2013, doi: 10.1007/s12029-013-9502-x.
[9] M. Liu, “Cutaneous metastasis of cholangiocarcinoma,” World Journal of Gastroenterology, vol. 21, no. 10, p. 3066, 2015, doi: 10.3748/wjg.v21.i10.3066.
[10] D. Harrington, C. George, H. Ibrahim, and S. Bhagani, “Cholangiocarcinoma with a metastatic umbilical lesion,” BMJ, p. k4041, Oct. 2018, doi: 10.1136/bmj.k4041.
[11] K. L. West, M. A. Selim, and P. K. Puri, “Cutaneous metastatic cholangiocarcinoma: a report of three cases and review of the literature,” Journal of Cutaneous Pathology, vol. 37, no. 12, pp. 1230–1236, Sep. 2010, doi: 10.1111/j.1600-0560.2010.01619.x.
[12] V. Muppidi, S. Meegada, J. D. Eaton, S. P. Nair, and R. Verma, “Recurrent Cholangiocarcinoma Presenting as Sister Mary Joseph Nodule After Liver Transplantation,” Cureus, Nov. 2020, doi: 10.7759/cureus.11673.
[13] M. L. Tan and A. K. Padhy, “Umbilical metastatic deposit from recurrent cholangiocarcinoma: F18-FDG PET-CT findings,” Singapore Medical Journal, vol. 52, no. 11, pp. e236-238, Nov. 2011, Accessed: Dec. 24, 2022. [Online]. Available: https://pubmed.ncbi.nlm.nih.gov/22173264/
[14] A. Balzani et al., “Cutaneous implantation metastasis of cholangiocarcinoma after percutaneous transhepatic biliary drainage,” Acta dermatovenerologica Croatica: ADC, vol. 13, no. 2, pp. 118–121, 2005. Available: https://pubmed.ncbi.nlm.nih.gov/16324426
Published
2023-01-03
How to Cite
Barbu, M., Mardare, M., Iosifescu, R., Bondoc, I., Văcărașu, A., Păunescu, A., Ali, L., Iacobescu, C., Călin, C., & Ginghină, O. (2023). SISTER MARY JOSEPH’S NODULE: FIRST SIGN OF CHOLANGIOCARCINOMA RECURRENCE. Romanian Journal of Clinical Research, 5(2). Retrieved from https://rjcronline.com/index.php/rjcr/article/view/159
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Articles
