FEATURES AND COMPLICATIONS IN NEONATES BORN AFTER ASSISTED REPRODUCTIVE TECHNOLOGIES
Keywords:
neonates, assisted reproductive technologies, IVF, outcomes
Abstract
Objectives: It is very well known that assisted reproductive technologies (ART) can significantly increase the birth rate; thus, special concern should be paid to the perinatal outcome and characteristics of these neonates.
Material and Methods: We analyzed the vital characteristics of the newborns conceived after in vitro fertilization (IVF) pregnancies born in the Obstetric-Neonatology Department of Emergency University Hospital Bucharest, Romania, between August 2021 and August 2022.
Outcomes: 22 infants were born after IVF-obtained pregnancies, 12 (54.54%) were preterm, 6 (22.72%) were twins, 3 (13.63%) were triplets, 12 had a low birth weight (LBW) (<2500 g), and 2 were small for the gestational age (SGA). All 22 neonates survived, 1 stillbirth from a twin pregnancy and 9 preterm infants were admitted to Neonatal Intensive Care Unit (NICU).
Conclusions: IVF neonates are at risk of prematurity, multiple births, LBW, SGA, and prolonged NICU hospitalization, but it is still uncertain whether the rate of multiple births, underlying infertility, or the IVF process represents the cause.
References
(1) Zegers-Hochschild, F.; Adamson, G. D.; de Mouzon, J.; Ishihara, O.; Mansour, R.; Nygren, K.; Sullivan, E.; Vanderpoel, S.; International Committee for Monitoring Assisted Reproductive Technology; World Health Organization. International Committee for Monitoring Assisted Reproductive Technology (ICMART) and the World Health Organization (WHO) Revised Glossary of ART Terminology, 2009. Fertil. Steril. 2009, 92 (5), 1520–1524. https://doi.org/10.1016/j.fertnstert.2009.09.009.
(2) ESHRE Special Interest Group of Embryology and Alpha Scientists in Reproductive Medicine. Electronic address: coticchio.biogenesi@grupposandonato.it. The Vienna Consensus: Report of an Expert Meeting on the Development of ART Laboratory Performance Indicators. Reprod. Biomed. Online 2017, 35 (5), 494–510. https://doi.org/10.1016/j.rbmo.2017.06.015.
(3) Adamsson G, Dyer S, Chambers G, Ishihara O, Mansour R, Banker M, et al. International Committee for Monitoring Assisted Reproductive Technologies (ICMART) Preliminary World Report on ART, 2015. Abstract ESHRE, Vienna. 2019.
(4) Reprod Biomed Soc Online. 2016 Jun;2:79-87. Published Online 2016 Jul 19.Doi:10.1016/j.Rbms.2016. 06.001.
(5) Trounson, A.; Mohr, L. Human Pregnancy Following Cryopreservation, Thawing and Transfer of an Eight-Cell Embryo. Nature 1983, 305 (5936), 707–709. https://doi.org/10.1038/305707a0.
(6) Haddad, M.; Stewart, J.; Xie, P.; Cheung, S.; Trout, A.; Keating, D.; Parrella, A.; Lawrence, S.; Rosenwaks, Z.; Palermo, G. D. Thoughts on the Popularity of ICSI. J. Assist. Reprod. Genet. 2021, 38 (1), 101–123. https://doi.org/10.1007/s10815-020-01987-0.
(7) The European IVF-Monitoring Consortium (EIM) for the European Society of Human Reproduction and Embryology (ESHRE); Wyns, C.; De Geyter, C.; Calhaz-Jorge, C.; Kupka, M. S.; Motrenko, T.; Smeenk, J.; Bergh, C.; Tandler-Schneider, A.; Rugescu, I. A.; Vidakovic, S.; Goossens, V. ART in Europe, 2017: Results Generated from European Registries by ESHRE†. Hum. Reprod. Open 2021, 2021 (3), hoab026. https://doi.org/10.1093/hropen/hoab026.
(8) Bănică, A. M.; Popescu, S. D.; Vlădăreanu, S. Maternal and Neonatal Outcomes Following in Vitro Fertilization: A Cohort Study in Romania. Exp. Ther. Med. 2022, 23 (1), 1–10. https://doi.org/10.3892/etm.2021.10956.
(9) Margan R et al. Socio-Economical, Legal and Ethical Issues Raised by Infertility and Assisted Reproductive Techniques in Romania, Revista de Cercetare Si Interventie Sociala, 2020,Vol70, PP 214-227, Doi.Org/10.33788/Rcis.70.13.
(10) Qin, J.-B.; Sheng, X.-Q.; Wu, D.; Gao, S.-Y.; You, Y.-P.; Yang, T.-B.; Wang, H. Worldwide Prevalence of Adverse Pregnancy Outcomes among Singleton Pregnancies after in Vitro Fertilization/Intracytoplasmic Sperm Injection: A Systematic Review and Meta-Analysis. Arch. Gynecol. Obstet. 2017, 295 (2), 285–301. https://doi.org/10.1007/s00404-016-4250-3.
(11) Qin, J.; Liu, X.; Sheng, X.; Wang, H.; Gao, S. Assisted Reproductive Technology and the Risk of Pregnancy-Related Complications and Adverse Pregnancy Outcomes in Singleton Pregnancies: A Meta-Analysis of Cohort Studies. Fertil. Steril. 2016, 105 (1), 73-85.e1-6. https://doi.org/10.1016/j.fertnstert. 2015.09.007.
(12) Maheshwari, A.; Pandey, S.; Amalraj Raja, E.; Shetty, A.; Hamilton, M.; Bhattacharya, S. Is Frozen Embryo Transfer Better for Mothers and Babies? Can Cumulative Meta-Analysis Provide a Definitive Answer? Hum. Reprod. Update 2018, 24 (1), 35–58. https://doi.org/10.1093/humupd/dmx031.
(13) Pinborg, A.; Wennerholm, U. B.; Romundstad, L. B.; Loft, A.; Aittomaki, K.; Söderström-Anttila, V.; Nygren, K. G.; Hazekamp, J.; Bergh, C. Why Do Singletons Conceived after Assisted Reproduction Technology Have Adverse Perinatal Outcome? Systematic Review and Meta-Analysis. Hum. Reprod. Update 2013, 19 (2), 87–104. https://doi.org/10.1093/humupd/dms044.
(14) Cavoretto, P. I.; Giorgione, V.; Sotiriadis, A.; Viganò, P.; Papaleo, E.; Galdini, A.; Gaeta, G.; Candiani, M. IVF/ICSI Treatment and the Risk of Iatrogenic Preterm Birth in Singleton Pregnancies: Systematic Review and Meta-Analysis of Cohort Studies. J. Matern.-Fetal Neonatal Med. Off. J. Eur. Assoc. Perinat. Med. Fed. Asia Ocean. Perinat. Soc. Int. Soc. Perinat. Obstet. 2022, 35 (10), 1987–1996. https://doi.org/10.1080/14767058.2020.1771690.
(15) Ogawa, K.; Urayama, K. Y.; Tanigaki, S.; Sago, H.; Sato, S.; Saito, S.; Morisaki, N. Association between Very Advanced Maternal Age and Adverse Pregnancy Outcomes: A Cross Sectional Japanese Study. BMC Pregnancy Childbirth 2017, 17 (1), 349. https://doi.org/10.1186/s12884-017-1540-0.
(16) Almasi-Hashiani, A.; Omani-Samani, R.; Mohammadi, M.; Amini, P.; Navid, B.; Alizadeh, A.; Khedmati Morasae, E.; Maroufizadeh, S. Assisted Reproductive Technology and the Risk of Preeclampsia: An Updated Systematic Review and Meta-Analysis. BMC Pregnancy Childbirth 2019, 19 (1), 149. https://doi.org/10.1186/s12884-019-2291-x.
(17) Thurin, A.; Hausken, J.; Hillensjö, T.; Jablonowska, B.; Pinborg, A.; Strandell, A.; Bergh, C. Elective Single-Embryo Transfer versus Double-Embryo Transfer in in Vitro Fertilization. N. Engl. J. Med. 2004, 351 (23), 2392–2402. https://doi.org/10.1056/NEJMoa041032.
(18) European IVF-monitoring Consortium (EIM)‡ for the European Society of Human Reproduction and Embryology (ESHRE); Wyns, C.; Bergh, C.; Calhaz-Jorge, C.; De Geyter, C.; Kupka, M. S.; Motrenko, T.; Rugescu, I.; Smeenk, J.; Tandler-Schneider, A.; Vidakovic, S.; Goossens, V. ART in Europe, 2016: Results Generated from European Registries by ESHRE. Hum. Reprod. Open 2020, 2020 (3), hoaa032. https://doi.org/10.1093/hropen/hoaa032.
(19) Lei, L.-L.; Lan, Y.-L.; Wang, S.-Y.; Feng, W.; Zhai, Z.-J. Perinatal Complications and Live-Birth Outcomes Following Assisted Reproductive Technology: A Retrospective Cohort Study. Chin. Med. J. (Engl.) 2019, 132 (20), 2408–2416. https://doi.org/10.1097/CM9.0000000000000484.
(20) Bergh, C.; Wennerholm, U.-B. Long-Term Health of Children Conceived after Assisted Reproductive Technology. Ups. J. Med. Sci. 2020, 125 (2), 152–157. https://doi.org/10.1080/03009734.2020.1729904.
(21) Wennberg, A. L.; Opdahl, S.; Bergh, C.; Aaris Henningsen, A.-K.; Gissler, M.; Romundstad, L. B.; Pinborg, A.; Tiitinen, A.; Skjærven, R.; Wennerholm, U.-B. Effect of Maternal Age on Maternal and Neonatal Outcomes after Assisted Reproductive Technology. Fertil. Steril. 2016, 106 (5), 1142-1149.e14. https://doi.org/10.1016/j.fertnstert.2016.06.021.
(22) Opdahl, S.; Henningsen, A. A.; Tiitinen, A.; Bergh, C.; Pinborg, A.; Romundstad, P. R.; Wennerholm, U. B.; Gissler, M.; Skjærven, R.; Romundstad, L. B. Risk of Hypertensive Disorders in Pregnancies Following Assisted Reproductive Technology: A Cohort Study from the CoNARTaS Group. Hum. Reprod. Oxf. Engl. 2015, 30 (7), 1724–1731. https://doi.org/10.1093/humrep/dev090.
(23) Bosdou, J. K.; Anagnostis, P.; Goulis, D. G.; Lainas, G. T.; Tarlatzis, B. C.; Grimbizis, G. F.; Kolibianakis, E. M. Risk of Gestational Diabetes Mellitus in Women Achieving Singleton Pregnancy Spontaneously or after ART: A Systematic Review and Meta-Analysis. Hum. Reprod. Update 2020, 26 (4), 514–544. https://doi.org/10.1093/humupd/dmaa011.
(24) Karami, M.; Jenabi, E.; Fereidooni, B. The Association of Placenta Previa and Assisted Reproductive Techniques: A Meta-Analysis. J. Matern.-Fetal Neonatal Med. Off. J. Eur. Assoc. Perinat. Med. Fed. Asia Ocean. Perinat. Soc. Int. Soc. Perinat. Obstet. 2018, 31 (14), 1940–1947. https://doi.org/10.1080/14767058.2017.1332035.
(2) ESHRE Special Interest Group of Embryology and Alpha Scientists in Reproductive Medicine. Electronic address: coticchio.biogenesi@grupposandonato.it. The Vienna Consensus: Report of an Expert Meeting on the Development of ART Laboratory Performance Indicators. Reprod. Biomed. Online 2017, 35 (5), 494–510. https://doi.org/10.1016/j.rbmo.2017.06.015.
(3) Adamsson G, Dyer S, Chambers G, Ishihara O, Mansour R, Banker M, et al. International Committee for Monitoring Assisted Reproductive Technologies (ICMART) Preliminary World Report on ART, 2015. Abstract ESHRE, Vienna. 2019.
(4) Reprod Biomed Soc Online. 2016 Jun;2:79-87. Published Online 2016 Jul 19.Doi:10.1016/j.Rbms.2016. 06.001.
(5) Trounson, A.; Mohr, L. Human Pregnancy Following Cryopreservation, Thawing and Transfer of an Eight-Cell Embryo. Nature 1983, 305 (5936), 707–709. https://doi.org/10.1038/305707a0.
(6) Haddad, M.; Stewart, J.; Xie, P.; Cheung, S.; Trout, A.; Keating, D.; Parrella, A.; Lawrence, S.; Rosenwaks, Z.; Palermo, G. D. Thoughts on the Popularity of ICSI. J. Assist. Reprod. Genet. 2021, 38 (1), 101–123. https://doi.org/10.1007/s10815-020-01987-0.
(7) The European IVF-Monitoring Consortium (EIM) for the European Society of Human Reproduction and Embryology (ESHRE); Wyns, C.; De Geyter, C.; Calhaz-Jorge, C.; Kupka, M. S.; Motrenko, T.; Smeenk, J.; Bergh, C.; Tandler-Schneider, A.; Rugescu, I. A.; Vidakovic, S.; Goossens, V. ART in Europe, 2017: Results Generated from European Registries by ESHRE†. Hum. Reprod. Open 2021, 2021 (3), hoab026. https://doi.org/10.1093/hropen/hoab026.
(8) Bănică, A. M.; Popescu, S. D.; Vlădăreanu, S. Maternal and Neonatal Outcomes Following in Vitro Fertilization: A Cohort Study in Romania. Exp. Ther. Med. 2022, 23 (1), 1–10. https://doi.org/10.3892/etm.2021.10956.
(9) Margan R et al. Socio-Economical, Legal and Ethical Issues Raised by Infertility and Assisted Reproductive Techniques in Romania, Revista de Cercetare Si Interventie Sociala, 2020,Vol70, PP 214-227, Doi.Org/10.33788/Rcis.70.13.
(10) Qin, J.-B.; Sheng, X.-Q.; Wu, D.; Gao, S.-Y.; You, Y.-P.; Yang, T.-B.; Wang, H. Worldwide Prevalence of Adverse Pregnancy Outcomes among Singleton Pregnancies after in Vitro Fertilization/Intracytoplasmic Sperm Injection: A Systematic Review and Meta-Analysis. Arch. Gynecol. Obstet. 2017, 295 (2), 285–301. https://doi.org/10.1007/s00404-016-4250-3.
(11) Qin, J.; Liu, X.; Sheng, X.; Wang, H.; Gao, S. Assisted Reproductive Technology and the Risk of Pregnancy-Related Complications and Adverse Pregnancy Outcomes in Singleton Pregnancies: A Meta-Analysis of Cohort Studies. Fertil. Steril. 2016, 105 (1), 73-85.e1-6. https://doi.org/10.1016/j.fertnstert. 2015.09.007.
(12) Maheshwari, A.; Pandey, S.; Amalraj Raja, E.; Shetty, A.; Hamilton, M.; Bhattacharya, S. Is Frozen Embryo Transfer Better for Mothers and Babies? Can Cumulative Meta-Analysis Provide a Definitive Answer? Hum. Reprod. Update 2018, 24 (1), 35–58. https://doi.org/10.1093/humupd/dmx031.
(13) Pinborg, A.; Wennerholm, U. B.; Romundstad, L. B.; Loft, A.; Aittomaki, K.; Söderström-Anttila, V.; Nygren, K. G.; Hazekamp, J.; Bergh, C. Why Do Singletons Conceived after Assisted Reproduction Technology Have Adverse Perinatal Outcome? Systematic Review and Meta-Analysis. Hum. Reprod. Update 2013, 19 (2), 87–104. https://doi.org/10.1093/humupd/dms044.
(14) Cavoretto, P. I.; Giorgione, V.; Sotiriadis, A.; Viganò, P.; Papaleo, E.; Galdini, A.; Gaeta, G.; Candiani, M. IVF/ICSI Treatment and the Risk of Iatrogenic Preterm Birth in Singleton Pregnancies: Systematic Review and Meta-Analysis of Cohort Studies. J. Matern.-Fetal Neonatal Med. Off. J. Eur. Assoc. Perinat. Med. Fed. Asia Ocean. Perinat. Soc. Int. Soc. Perinat. Obstet. 2022, 35 (10), 1987–1996. https://doi.org/10.1080/14767058.2020.1771690.
(15) Ogawa, K.; Urayama, K. Y.; Tanigaki, S.; Sago, H.; Sato, S.; Saito, S.; Morisaki, N. Association between Very Advanced Maternal Age and Adverse Pregnancy Outcomes: A Cross Sectional Japanese Study. BMC Pregnancy Childbirth 2017, 17 (1), 349. https://doi.org/10.1186/s12884-017-1540-0.
(16) Almasi-Hashiani, A.; Omani-Samani, R.; Mohammadi, M.; Amini, P.; Navid, B.; Alizadeh, A.; Khedmati Morasae, E.; Maroufizadeh, S. Assisted Reproductive Technology and the Risk of Preeclampsia: An Updated Systematic Review and Meta-Analysis. BMC Pregnancy Childbirth 2019, 19 (1), 149. https://doi.org/10.1186/s12884-019-2291-x.
(17) Thurin, A.; Hausken, J.; Hillensjö, T.; Jablonowska, B.; Pinborg, A.; Strandell, A.; Bergh, C. Elective Single-Embryo Transfer versus Double-Embryo Transfer in in Vitro Fertilization. N. Engl. J. Med. 2004, 351 (23), 2392–2402. https://doi.org/10.1056/NEJMoa041032.
(18) European IVF-monitoring Consortium (EIM)‡ for the European Society of Human Reproduction and Embryology (ESHRE); Wyns, C.; Bergh, C.; Calhaz-Jorge, C.; De Geyter, C.; Kupka, M. S.; Motrenko, T.; Rugescu, I.; Smeenk, J.; Tandler-Schneider, A.; Vidakovic, S.; Goossens, V. ART in Europe, 2016: Results Generated from European Registries by ESHRE. Hum. Reprod. Open 2020, 2020 (3), hoaa032. https://doi.org/10.1093/hropen/hoaa032.
(19) Lei, L.-L.; Lan, Y.-L.; Wang, S.-Y.; Feng, W.; Zhai, Z.-J. Perinatal Complications and Live-Birth Outcomes Following Assisted Reproductive Technology: A Retrospective Cohort Study. Chin. Med. J. (Engl.) 2019, 132 (20), 2408–2416. https://doi.org/10.1097/CM9.0000000000000484.
(20) Bergh, C.; Wennerholm, U.-B. Long-Term Health of Children Conceived after Assisted Reproductive Technology. Ups. J. Med. Sci. 2020, 125 (2), 152–157. https://doi.org/10.1080/03009734.2020.1729904.
(21) Wennberg, A. L.; Opdahl, S.; Bergh, C.; Aaris Henningsen, A.-K.; Gissler, M.; Romundstad, L. B.; Pinborg, A.; Tiitinen, A.; Skjærven, R.; Wennerholm, U.-B. Effect of Maternal Age on Maternal and Neonatal Outcomes after Assisted Reproductive Technology. Fertil. Steril. 2016, 106 (5), 1142-1149.e14. https://doi.org/10.1016/j.fertnstert.2016.06.021.
(22) Opdahl, S.; Henningsen, A. A.; Tiitinen, A.; Bergh, C.; Pinborg, A.; Romundstad, P. R.; Wennerholm, U. B.; Gissler, M.; Skjærven, R.; Romundstad, L. B. Risk of Hypertensive Disorders in Pregnancies Following Assisted Reproductive Technology: A Cohort Study from the CoNARTaS Group. Hum. Reprod. Oxf. Engl. 2015, 30 (7), 1724–1731. https://doi.org/10.1093/humrep/dev090.
(23) Bosdou, J. K.; Anagnostis, P.; Goulis, D. G.; Lainas, G. T.; Tarlatzis, B. C.; Grimbizis, G. F.; Kolibianakis, E. M. Risk of Gestational Diabetes Mellitus in Women Achieving Singleton Pregnancy Spontaneously or after ART: A Systematic Review and Meta-Analysis. Hum. Reprod. Update 2020, 26 (4), 514–544. https://doi.org/10.1093/humupd/dmaa011.
(24) Karami, M.; Jenabi, E.; Fereidooni, B. The Association of Placenta Previa and Assisted Reproductive Techniques: A Meta-Analysis. J. Matern.-Fetal Neonatal Med. Off. J. Eur. Assoc. Perinat. Med. Fed. Asia Ocean. Perinat. Soc. Int. Soc. Perinat. Obstet. 2018, 31 (14), 1940–1947. https://doi.org/10.1080/14767058.2017.1332035.
Published
2023-03-11
How to Cite
Vasilescu, D., Dan, A., Stefan, L., Borș, R., Varlas, V., & Cîrstoiu, M. (2023). FEATURES AND COMPLICATIONS IN NEONATES BORN AFTER ASSISTED REPRODUCTIVE TECHNOLOGIES. Romanian Journal of Clinical Research, 6(1). Retrieved from https://rjcronline.com/index.php/rjcr/article/view/171
Section
Articles
