• Florica Sandru Department of Dermatology, ”Carol Davila” University of Medicine and Pharmacy, Bucharest
  • Bianca Maria Petrescu Department of Dermatology, ”Elias” University Emergency Hospital, Bucharest
  • Mihai Cristian Dumitrascu Department of Obstetrics and Gynecology, 'Carol Davila' University of Medicine and Pharmacy Bucharest
  • Răzvan Cosmin Petca Department of Urology, 'Carol Davila' University of Medicine and Pharmacy Bucharest
  • Andreea Maria Radu Dermatology Department, "Elias" University Emergency Hospital Bucharest
  • Aida Petca Department of Obstetrics and Gynecology, 'Carol Davila' University of Medicine and Pharmacy Bucharest
Keywords: superficial spreading melanoma; dermoscopy; immunohistochemistry; early detection.


Melanoma stands as the most lethal variant of skin malignancies. During its incipient stages, surgical intervention alone can yield successful treatment outcomes, resulting in high survival rates. However, once metastasis occurs, the survival rates substantially decline. In this case study, we present the journey of a 42-year-old woman with thalassemia minor and a benign breast nodule, highlighting the critical role of early detection and specialized medical care in securing the most favorable prognosis for patients. Upon presentation to the Dermatology department, a thorough evaluation unveiled a unique tumor formation on the patient’s skin, approximately 2.5 cm in diameter, with irregular margins. Importantly, the dermatoscopic examination showed a polymorphic appearance with atypical pigment network and central regression, findings that immediately raised concerns. Subsequent surgical excision, coupled with histopathological and immunohistochemical assessments, confirmed a superficial spreading melanoma with a Clark level IV invasion. The development of this malignancy has occurred concurrently with a preexisting intradermal melanocytic nevus. This study underscores the value of early detection and specialized medical intervention in melanoma cases, showcasing the transformative impact of timely medical attention on treatment outcomes and patient well-being.


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How to Cite
Sandru, F., Petrescu, B., Dumitrascu, M., Petca, R., Radu, A., & Petca, A. (2024). EARLY DETECTION AND MANAGEMENT OF MELANOMA: A CASE REPORT. Romanian Journal of Clinical Research, 7(1). https://doi.org/10.33695/rjcr.v7i1.207