• Florica Sandru Elias Emergency University Hospital, Bucharest, UMF ” Carol Davila” Bucharest
  • Mihai Dumitrascu Emergency University Hospital Bucharest, UMF ”Carol Davila” Bucharest
  • Daniel-Vasile Balaban
  • Razvan-Cosmin Petca
  • Adelina Popa Elias Emergency University Hospital, Bucharest
  • Elis Curtmola
  • Raluca Gabriela Miulescu
Keywords: linear Ig A bullous dermatosis (LABD), blistering disease, colchicine, dapsone, herpetiform dermatitis, bullous pemphigoid.


Linear IgA bullous dermatosis (LABD) is a rare, immune-mediated cutaneous pathology, characterized by IgA deposits along the basal membrane. Clinically, it manifests as an eruption, consisting of vesicles and bullae, with herpetiform distribution, on erythematous and/or normal skin. The lesions are located symmetrically, at the level of the trunk and extremities. Clinically, diagnosis can be difficult because it can be easily mistaken with dermatitis herpetiformis or bullous pemphigoid.     We present the case of a 79-years-old woman, without significant comorbidities, who developed a vasculo-bullous eruption, intensely itchy, located symmetrically on trunk and extremities, evolving for 4 years. We performed a skin biopsy, with histopathological examination and direct immunofluorescence, which revealed: sub epidermal vesicular-bullous lesion and dermal infiltrate with numerous neutrophils and eosinophils; IgA - continuous linear positivity at the dermal-epidermal junction. Thus, the diagnosis of LABD was established. The treatment consisted of systemic corticosteroids, colchicine, and antihistamines, with favorable evolution.    The management of these patients can be challenging, as LABD can be induced by certain drugs, and may also be associated with lymphoid malignancies.


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How to Cite
Sandru, F., Dumitrascu, M., Balaban, D.-V., Petca, R.-C., Popa, A., Curtmola, E., & Miulescu, R. (2019). LINEAR IG A BULLOUS DERMATOSIS – CASE REPORT. Romanian Journal of Clinical Research, 2(2).