DERMOSCOPY AND HISTOPATHOLOGY CORRELATIONS IN MELANOMA - CAN DERMOSCOPIC CRITERIA PREDICT THE SEVERITY OF MELANOMA?
Keywords:
melanoma, dermoscopy, histopathology, severity, Breslow index
Abstract
Dermoscopy-histopathology correlations have been studied for a few years now. While difficult to assess, the pathology correspondence of each dermoscopic criterion would offer great insight into the melanoma evolution. We attempted to take a closer look into the melanoma dermoscopic clues and the severity of the tumor. In order to determine a link between the 10 specific melanoma criteria and its stage we searched for correlations between dermoscopy and classic histopathologic parameters such as Breslow thickness, Clark index, mitosis index, the presence of ulceration, regression, inflammatory infiltrate, lympho-vascular invasion, cases satellite tumor nodules or perineural invasion. We evaluated the dermoscopy and pathology of 58 melanocytic tumors (35 melanomas, 6 atypical nevi and 17 common nevi) in a prospective study. The atypical network proved to be correlated with thinner and more superficial melanomas. On the other hand, vascular dermoscopy patterns (dotted, polymorphous, serpiginous vessels, milky red areas and red globules) were seen generally in thicker, more invasive and more advanced melanomas. The results were consistent with other studies performed in the past.
References
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[2] F. Nachbar et al., “The ABCD rule of dermatoscopy,” J. Am. Acad. Dermatol., 1994.
[3] J. S. Henning et al., “The CASH (color, architecture, symmetry, and homogeneity) algorithm for dermoscopy,” J. Am. Acad. Dermatol., vol. 56, no. 1, pp. 45–52, 2007.
[4] I. Zalaudek et al., “Three-point checklist of dermoscopy: An open internet study,” Br. J. Dermatol., vol. 154, no. 3, pp. 431–437, 2006.
[5] H. A. Haenssle et al., “Seven-point checklist for dermatoscopy: Performance during 10 years of prospective surveillance of patients at increased melanoma risk,” J. Am. Acad. Dermatol., vol. 62, no. 5, pp. 785–793, 2010.
[6] P. Bourne, C. Rosendahl, J. Keir, and A. Cameron, “BLINCK—A diagnostic algorithm for skin cancer diagnosis combining clinical features with dermatoscopy findings,” Dermatol. Pract. Concept., vol. 2, no. 2, pp. 55–61, 2012.
[7] C. Ciudad-Blanco, J. A. Avilés-Izquierdo, P. Lázaro-Ochaita, and R. Suárez-Fernández, “Dermoscopic findings for the early detection of melanoma: An analysis of 200 cases,” Actas Dermosifiliogr., 2014.
[8] V. P. M. da Silva, J. K. Ikino, M. M. Sens, D. H. Nunes, and G. Di Giunta, “Dermoscopic features of thin melanomas: a comparative study of melanoma in situ and invasive melanomas smaller than or equal to 1mm,” An. Bras. Dermatol., 2013.
[9] T. Russo et al., “Dermoscopy pathology correlation in melanoma,” Journal of Dermatology. 2017.
[10] R. P. Braun, “Histopathologic Correlation in Dermoscopy,” vol. 139, pp. 349–351, 2017.
[11] D. Massi, V. De Giorgi, and H. P. Soyer, “Histopathologic correlates of dermoscopic criteria,” Dermatol. Clin., vol. 19, no. 2, pp. 259–268, 2001.
[12] I. A. for R. on C. W. H. O. Iarc., “GLOBOCAN 2012: Estimated Cancer Incidence, Mortality and Prevalence Worldwide in 2012.,” Globocan, 2012.
[13] E. Linos, S. M. Swetter, M. G. Cockburn, G. A. Colditz, and C. A. Clarke, “Increasing burden of melanoma in the United States,” J. Invest. Dermatol., 2009.
[14] A. A. Marghoob, N. Jaimes, S. Editor, H. Tsao, D. Editor, and R. Corona, “Dermoscopic evaluation of skin lesions,” pp. 1–65, 2012.
[15] I. Kovalyshyn, S. W. Dusza, K. Siamas, A. C. Halpern, G. Argenziano, and A. A. Marghoob, “The impact of physician screening on melanoma detection,” Arch. Dermatol., vol. 147, no. 11, pp. 1269–1275, 2011.
[16] M. B. Lens and M. Dawes, “Global perspectives of contemporary epidemiological trends of cutaneous malignant melanoma,” British Journal of Dermatology. 2004.
[17] G. Argenziano et al., “Seven-point checklist of dermoscopy revisited,” Br. J. Dermatol., vol. 164, no. 4, pp. 785–790, 2011.
[18] H. P. Soyer et al., “Three-point checklist of dermoscopy: A new screening method for early detection of melanoma,” Dermatology, vol. 208, no. 1, pp. 27–31, 2004.
[19] M. A. Pizzichetta, V. Canzonieri, P. H. Soyer, P. Rubegni, R. Talamini, and C. Massone, “Negative pigment network and shiny white streaks: A dermoscopic- pathological correlation study,” Am. J. Dermatopathol., 2014.
[20] R. Botella-Estrada, C. Requena, V. Traves, E. Nagore, and C. Guillen, “Chrysalis and negative pigment network in Spitz nevi,” Am. J. Dermatopathol., 2012.
[21] G. P. Lozzi, D. Piccolo, T. Micantonio, D. Altamura, and K. Peris, “Early melanomas dermoscopically characterized by reticular depigmentation [12],” Archives of Dermatology. 2007.
[22] G. G. Rezze, A. P. Scramim, R. I. Neves, and G. Landman, “Structural correlations between dermoscopic features of cutaneous melanomas and histopathology using transverse sections,” Am. J. Dermatopathol., 2006.
[23] S. W. Menzies et al., “Dermoscopic evaluation of amelanotic and hypomelanotic melanoma,” Arch. Dermatol., vol. 144, no. 9, pp. 1120–1127, 2008.
[24] S. W. Menzies et al., “Dermoscopic evaluation of nodular melanoma,” JAMA Dermatology, vol. 149, no. 6, pp. 699–709, 2013.
[25] I. Zalaudek, J. Kreusch, J. Giacomel, G. Ferrara, C. Catrical, and G. Argenziano, “How to diagnose nonpigmented skin tumors: A review of vascular structures seen with dermoscopy: Part I. Melanocytic skin tumors,” Journal of the American Academy of Dermatology. 2010.
[26] G. Argenziano et al., “Vascular Structures in Skin Tumors,” Arch. Dermatol., vol. 140, no. 12, 2004.
[27] A. Bono et al., “Clinical and dermatoscopic diagnosis of early amelanotic melanoma,” Melanoma Res., vol. 11, no. 5, pp. 491–494, 2001.
[28] I. Zalaudek, G. Argenziano, H. Kerl, and H. P. Soyer, “Amelanotic / Hypomelanotic Melanoma ± Is Dermatoscopy Useful For Diagnosis ? Ist die Auflichtmikroskopie hilfreich fu,” vol. 2003, no. Band 1, pp. 369–373, 2003.
[29] Y. Togawa, “Review of vasculature visualized on dermoscopy,” J. Dermatol., vol. 44, no. 5, pp. 525–532, 2017.
[30] A. A. Marghoob and R. Braun, “Proposal for a revised 2-step algorithm for the classification of lesions of the skin using dermoscopy,” Archives of Dermatology. 2010.
Published
2021-07-31
How to Cite
Coman, A., Antohe, M., Brinzea, A., Nedelcu, R., Moroianu, A., Turcu, G., Balaban, M., David Niculescu, M. C., Balasescu, E., Hulea, I., Zurac, S., Cioplea, M., Popp, C., Nichita, L., Popescu, R., Popescu, C., & Ion, D. (2021). DERMOSCOPY AND HISTOPATHOLOGY CORRELATIONS IN MELANOMA - CAN DERMOSCOPIC CRITERIA PREDICT THE SEVERITY OF MELANOMA?. Romanian Journal of Clinical Research, 4(1). https://doi.org/10.33695/rjcr.v4i1.68
Section
Articles
