THE IMPACT OF RHEUMATIC AND GASTROINTESTINAL AUTOIMMUNE DISEASES ON PREGNANCY

Andreea Grațiana Boiangiu; Anca Bobircă; Andra Bălănescu; Simona Popescu; Sorina Nechita; Mona Zvanca; Radu Vlădăreanu; Simona Vlădăreanu

doi:10.33695/rjcr.v4i2.90

Andreea Grațiana Boiangiu “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania & Obstetrics and Gynecology Department, “Elias” University Hospital, Bucharest, Romania
Anca Bobircă “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania & Internal Medicine and Rheumatology Department, “Dr. I. Cantacuzino” Clinical Hospital, Bucharest, Romania
Andra Bălănescu “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania & Internal Medicine and Rheumatology Department “Sf. Maria” Hospital, Bucharest, Romania
Simona Popescu “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania & Neonatology Department, “Elias” University Hospital, Bucharest, Romania
Sorina Nechita Department of General Surgery, University Emergency Hospital of Bucharest, Bucharest, Romania
Mona Zvanca “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania & Obstetrics and Gynecology Department, “Elias” University Hospital, Bucharest, Romania
Radu Vlădăreanu “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania & Obstetrics and Gynecology Department, “Elias” University Hospital, Bucharest, Romania
Simona Vlădăreanu “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania & Neonatology Department, “Elias” University Hospital, Bucharest, Romania

DOI: https://doi.org/10.33695/rjcr.v4i2.90

Keywords: pregnancy, autoimmune disease, fetal complications, treatment

Abstract

Pregnancy promotes immune and endocrine adjustments in order to facilitate nidation, placentation and fetal development, inducing an immunological reset and triggering a potential autoimmune disease. The aim of the study is to analyze the impact of an underlying rheumatic or gastrointestinal autoimmune disease on pregnancy. The study is retrospective, unicentric, and included a group of 70 patients. The awareness regarding reproduction in women with rheumatic diseases made pregnancies possible and with fewer complications along the way, imputing interdisciplinary management and pre-conceptional counselling. Pregnancy complications as pregnancy loss, cesarean delivery, preeclampsia, intrauterine growth restriction, preterm birth are more often among pregnant women with autoimmune diseases, but severe complications like perinatal deaths and structural malformation are rare. The take home message of these research is that pregnancy in woman with autoimmune diseases should be multidisciplinary monitored due to possible placental transfer of maternal autoantibodies, the possible effects of maternal medications on the fetus and the newborn.

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